X4Oxygen Knowledge Hub
X4Oxygen Knowledge Hub
Gain exclusive insights into the world of hyperbaric oxygen therapy. From clinical studies to product tutorials – this Knowledge Hub combines knowledge with expertise.
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Study
HBOT in Post-COVID and ME/CFS: Prospective Observational Study at Charité (NCT06118138)
Charité cohort (n=60): The course of ME/CFS after COVID under HBOT (2 ATA, 90 min) is being prospectively recorded. Primary endpoint: SF-36 PF ≥ +10 points at 4 weeks after completion of HBOT
10
min Lesezeit
0
Study
HIIT in Cancer: Better Fitness & Function Compared to Conventional Endurance Training?
HIIT improves function and VO₂ in cancer patients; compared to MICT, a benefit for VO₂ is observed (SMD 0.37; p=0.009). Training effects increase with total volume.
T. Neuendorf; R. Haase; S. Schroeder; M. Schumann; N. Nitzsche
10
min Lesezeit
2023
Study
HBOT can induce angiogenesis and restore erectile function.
HBOT (40 sessions, 2 ATA) significantly improves IIEF scores and increases penile perfusion (K-trans +153%); 80% report benefit. Findings suggest angiogenesis as the underlying mechanism.
Hadanny A; Lang E; Copel L; Meir O; Bechor Y; Fishlev G; Bergan J; Friedman M; Zisman A; Efrati S.
10
min Lesezeit
2018
Study
HBOT for the Reversal of Post-COVID Cognitive Impairment (Commentary)
Commentary: Hypoxemia Drives Post-COVID Cognitive Impairment. HBOT May Enhance Tissue Oxygenation & Neuroplasticity; Case Report and Small RCT Demonstrate Cognitive and MRI Improvements.
Chia Siang Kow; Dinesh S. Ramachandram; Syed S. Hasan
10
min Lesezeit
2022
Study
HBOT for the Treatment of Long COVID
The study investigates the use of hyperbaric oxygen therapy (HBOT) as a potential treatment for Long COVID.
Tim Robbins, Michael Gonevski, Cain Clark, Sudhanshu Baitule, Kavi Sharma, Angel Magar, Kiran Patel, Sailesh Sankar, Ioannis Kyrou, Asad Ali, Harpal S. Randeva.
10
min Lesezeit
2021
Study
HBOT Improves Neurocognitive Function and Post-COVID Symptoms
HBOT (40 sessions, 2 ATA, 90 min) improved cognition, energy, sleep, psychological symptoms, and pain in Long COVID; parallel improvements in brain perfusion and microstructure were observed.
Zilberman-Itskovich S, Catalogna M, Sasson E, Elman-Shina K, Hadanny A, Lang E, Finci S, Polak N, Fishlev G, Korin C, Shorer R, Parag Y, Sova M, Efrati S
1
min Lesezeit
Study
HBOT Reduces Vascular Dysfunction and Amyloid Burden (Alzheimer’s Mouse Model)
HBOT: CBF↑, hypoxia↓; in AD mice, amyloid↓. In elderly patients (n=6), CBF and cognitive scores improved after 60 sessions (2 ATA, 90 min).
Ronit Shapira; Amos Gdalyahu; Irit Gottfried; Efrat Sasson; Amir Hadanny; Shai Efrati; Pablo Blinder; Uri Ashery.
1
min Lesezeit
Study
HBOT can alleviate fibromyalgia syndrome
The study investigates the effects of hyperbaric oxygen therapy (HBOT) on telomere length and immune response in isolated blood cells.
Hachmo Y; Hadanny A; Abu Hamed R; Daniel-Kotovsky M; Catalogna M; Fishlev G; Lang E; Polak N; Doenyas K; Friedman M; Zemel Y; Bechor Y; Efrati S
10
min Lesezeit
2020
Study
HBOT Lengthens Telomeres and Reduces Immune Senescence in Older Adults (Prospective Study)
HBOT (60 sessions, 2 ATA) lengthens telomeres (>20%) in T, B, and NK cells and reduces senescent T cells (CD4⁺CD28⁻ −37%). Evidence of immunological rejuvenation.
Hachmo Y; Hadanny A; Abu Hamed R; Daniel-Kotovsky M; Catalogna M; Fishlev G; Lang E; Polak N; Doenyas K; Friedman M; Zemel Y; Bechor Y; Efrati S.
5
min Lesezeit
2020
Study
HBOT in Long COVID (HOT-LoCO): Interim Safety Analysis of a Randomized, Placebo-Controlled Trial
RCT interim analysis (n=20): No SAEs, 31 AEs/60% (mostly mild, cough/chest discomfort). DSMB assessed HBOT safety as favorable; baseline values in Long COVID markedly reduced.
Anders Kjellberg; Adrian Hassler; Emil Boström; Sara El Gharbi; Sarah Al-Ezerjawi; Jan Kowalski; Kenny A. Rodriguez-Wallberg; Judith Bruchfeld; Marcus Ståhlberg; Malin Nygren-Bonnier; Michael Runold; Peter Lindholm.
10
min Lesezeit
2023
Study
HBOT: From Mechanisms to Cognitive Enhancement (Review)
Review: Intermittent HBOT activates SIRT1/Nrf2/HIF-1α, improves CBF, metabolism & microstructure, and is associated with cognitive gains in stroke, TBI, MCI/AD, and healthy individuals.
Irit Gottfried; Nofar Schottlender; Uri Ashery.
1
min Lesezeit
Study
HBOT, Mitochondria & Oxidative Stress: What Does the Evidence Say?
Intermittent HBOT improves mitochondrial function and reduces oxidative stress: short-term ROS↑, long-term via Nrf2/SIRT1/HIF-1α antioxidant systems↑ and ROS↓.
Nofar Schottlender; Irit Gottfried; Uri Ashery
10
min Lesezeit
2021
Study
HBOT and Skin Aging: More Collagen, Longer Elastin Fibers, Less Senescence
hbot-hautalterung-kollagen-angiogenese-seneszenz-2021
Yafit Hachmo; Amir Hadanny; Sonia Mendelovic; Pnina Hillman; Eyal Shapira; Geva Landau; Hadar Gattegno; Avi Zrachya; Malka Daniel-Kotovsky; Merav Catalogna; Gregory Fishlev; Erez Lang; Nir Polak; Keren Doenyas; Mony Friedman; Yonatan Zemel; Yair Bechor; Shai Efrati
20
min Lesezeit
2021
Study
Hyperbaric Oxygen Therapy (HBOT) Alters Gene Expression in Seniors: Prospective Study
HBOT (60 sessions) markedly alters the blood transcriptome in seniors (1,912 genes). After 2 weeks, 19 genes remain affected, including ABCA13. Short-term dominant, partially lasting effect.
Amir Hadanny; Relly Forer; Dina Volodarsky; Malka Daniel-Kotovsky; Merav Catalogna; Yonatan Zemel; Yair Bechor; Shai Efrati
20
min Lesezeit
Study
HBOT increases telomere length and reduces immunosenescence in blood cells
HBOT (60 sessions) lengthens telomeres (>20%) in T, B and NK cells and reduces senescent T cells (−37% CD4⁺). Evidence of immunological rejuvenation.
Yafit Hachmo; Amir Hadanny; Ramzia Abu Hamed; Malka Daniel-Kotovsky; Merav Catalogna; Gregory Fishlev; Erez Lang; Nir Polak; Keren Doenyas; Mony Friedman; Yonatan Zemel; Yair Bechor; Shai Efrati
1
min Lesezeit
Study
HBOT in Post-COVID and ME/CFS: Prospective Observational Study at Charité (NCT06118138)
Charité cohort (n=60): The course of ME/CFS after COVID under HBOT (2 ATA, 90 min) is being prospectively recorded. Primary endpoint: SF-36 PF ≥ +10 points at 4 weeks after completion of HBOT
10
min Lesezeit
0
Study
HIIT in Cancer: Better Fitness & Function Compared to Conventional Endurance Training?
HIIT improves function and VO₂ in cancer patients; compared to MICT, a benefit for VO₂ is observed (SMD 0.37; p=0.009). Training effects increase with total volume.
T. Neuendorf; R. Haase; S. Schroeder; M. Schumann; N. Nitzsche
10
min Lesezeit
2023
Study
HBOT can induce angiogenesis and restore erectile function.
HBOT (40 sessions, 2 ATA) significantly improves IIEF scores and increases penile perfusion (K-trans +153%); 80% report benefit. Findings suggest angiogenesis as the underlying mechanism.
Hadanny A; Lang E; Copel L; Meir O; Bechor Y; Fishlev G; Bergan J; Friedman M; Zisman A; Efrati S.
10
min Lesezeit
2018
Study
HBOT for the Reversal of Post-COVID Cognitive Impairment (Commentary)
Commentary: Hypoxemia Drives Post-COVID Cognitive Impairment. HBOT May Enhance Tissue Oxygenation & Neuroplasticity; Case Report and Small RCT Demonstrate Cognitive and MRI Improvements.
Chia Siang Kow; Dinesh S. Ramachandram; Syed S. Hasan
10
min Lesezeit
2022
Study
HBOT for the Treatment of Long COVID
The study investigates the use of hyperbaric oxygen therapy (HBOT) as a potential treatment for Long COVID.
Tim Robbins, Michael Gonevski, Cain Clark, Sudhanshu Baitule, Kavi Sharma, Angel Magar, Kiran Patel, Sailesh Sankar, Ioannis Kyrou, Asad Ali, Harpal S. Randeva.
10
min Lesezeit
2021
Study
HBOT Improves Neurocognitive Function and Post-COVID Symptoms
HBOT (40 sessions, 2 ATA, 90 min) improved cognition, energy, sleep, psychological symptoms, and pain in Long COVID; parallel improvements in brain perfusion and microstructure were observed.
Zilberman-Itskovich S, Catalogna M, Sasson E, Elman-Shina K, Hadanny A, Lang E, Finci S, Polak N, Fishlev G, Korin C, Shorer R, Parag Y, Sova M, Efrati S
1
min Lesezeit
Study
HBOT Reduces Vascular Dysfunction and Amyloid Burden (Alzheimer’s Mouse Model)
HBOT: CBF↑, hypoxia↓; in AD mice, amyloid↓. In elderly patients (n=6), CBF and cognitive scores improved after 60 sessions (2 ATA, 90 min).
Ronit Shapira; Amos Gdalyahu; Irit Gottfried; Efrat Sasson; Amir Hadanny; Shai Efrati; Pablo Blinder; Uri Ashery.
1
min Lesezeit
Study
HBOT can alleviate fibromyalgia syndrome
The study investigates the effects of hyperbaric oxygen therapy (HBOT) on telomere length and immune response in isolated blood cells.
Hachmo Y; Hadanny A; Abu Hamed R; Daniel-Kotovsky M; Catalogna M; Fishlev G; Lang E; Polak N; Doenyas K; Friedman M; Zemel Y; Bechor Y; Efrati S
10
min Lesezeit
2020
Study
HBOT Lengthens Telomeres and Reduces Immune Senescence in Older Adults (Prospective Study)
HBOT (60 sessions, 2 ATA) lengthens telomeres (>20%) in T, B, and NK cells and reduces senescent T cells (CD4⁺CD28⁻ −37%). Evidence of immunological rejuvenation.
Hachmo Y; Hadanny A; Abu Hamed R; Daniel-Kotovsky M; Catalogna M; Fishlev G; Lang E; Polak N; Doenyas K; Friedman M; Zemel Y; Bechor Y; Efrati S.
5
min Lesezeit
2020
Study
HBOT in Long COVID (HOT-LoCO): Interim Safety Analysis of a Randomized, Placebo-Controlled Trial
RCT interim analysis (n=20): No SAEs, 31 AEs/60% (mostly mild, cough/chest discomfort). DSMB assessed HBOT safety as favorable; baseline values in Long COVID markedly reduced.
Anders Kjellberg; Adrian Hassler; Emil Boström; Sara El Gharbi; Sarah Al-Ezerjawi; Jan Kowalski; Kenny A. Rodriguez-Wallberg; Judith Bruchfeld; Marcus Ståhlberg; Malin Nygren-Bonnier; Michael Runold; Peter Lindholm.
10
min Lesezeit
2023
Study
HBOT: From Mechanisms to Cognitive Enhancement (Review)
Review: Intermittent HBOT activates SIRT1/Nrf2/HIF-1α, improves CBF, metabolism & microstructure, and is associated with cognitive gains in stroke, TBI, MCI/AD, and healthy individuals.
Irit Gottfried; Nofar Schottlender; Uri Ashery.
1
min Lesezeit
Study
HBOT, Mitochondria & Oxidative Stress: What Does the Evidence Say?
Intermittent HBOT improves mitochondrial function and reduces oxidative stress: short-term ROS↑, long-term via Nrf2/SIRT1/HIF-1α antioxidant systems↑ and ROS↓.
Nofar Schottlender; Irit Gottfried; Uri Ashery
10
min Lesezeit
2021
Study
HBOT and Skin Aging: More Collagen, Longer Elastin Fibers, Less Senescence
hbot-hautalterung-kollagen-angiogenese-seneszenz-2021
Yafit Hachmo; Amir Hadanny; Sonia Mendelovic; Pnina Hillman; Eyal Shapira; Geva Landau; Hadar Gattegno; Avi Zrachya; Malka Daniel-Kotovsky; Merav Catalogna; Gregory Fishlev; Erez Lang; Nir Polak; Keren Doenyas; Mony Friedman; Yonatan Zemel; Yair Bechor; Shai Efrati
20
min Lesezeit
2021
Study
Hyperbaric Oxygen Therapy (HBOT) Alters Gene Expression in Seniors: Prospective Study
HBOT (60 sessions) markedly alters the blood transcriptome in seniors (1,912 genes). After 2 weeks, 19 genes remain affected, including ABCA13. Short-term dominant, partially lasting effect.
Amir Hadanny; Relly Forer; Dina Volodarsky; Malka Daniel-Kotovsky; Merav Catalogna; Yonatan Zemel; Yair Bechor; Shai Efrati
20
min Lesezeit
Study
HBOT increases telomere length and reduces immunosenescence in blood cells
HBOT (60 sessions) lengthens telomeres (>20%) in T, B and NK cells and reduces senescent T cells (−37% CD4⁺). Evidence of immunological rejuvenation.
Yafit Hachmo; Amir Hadanny; Ramzia Abu Hamed; Malka Daniel-Kotovsky; Merav Catalogna; Gregory Fishlev; Erez Lang; Nir Polak; Keren Doenyas; Mony Friedman; Yonatan Zemel; Yair Bechor; Shai Efrati
1
min Lesezeit
X4 Innovation © 2025 All Rights reserved
X4 Innovation © 2025 All Rights reserved
X4 Innovation © 2025 All Rights reserved