Studies

HBOT Improves Neurocognitive Function and Post-COVID Symptoms

HBOT (40 sessions, 2 ATA, 90 min) improved cognition, energy, sleep, psychological symptoms, and pain in Long COVID; parallel improvements in brain perfusion and microstructure were observed.

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Many People Continue to Suffer from Post-COVID Symptoms – HBOT Shows Promising Results

Many individuals experience persistent physical, neurocognitive, and psychological symptoms following COVID-19 infection, often referred to as Post-COVID-19 syndrome. A recent investigation shows that hyperbaric oxygen therapy (HBOT) may alleviate these symptoms and improve brain function.

What is Hyperbaric Oxygen Therapy?

HBOT involves patients breathing 100% oxygen under elevated pressure inside a hyperbaric chamber. This increases the amount of oxygen dissolved in the blood and tissues, supporting healing processes and neuroplasticity – the brain’s ability to adapt and regenerate.

Study Design

In a randomized, double-blind, sham-controlled trial, 73 patients with persistent Post-COVID symptoms at least three months after confirmed SARS-CoV-2 infection were enrolled.

  • HBOT group: 37 patients received 40 HBOT sessions.

  • Control group: 36 patients received sham treatment.

Key Findings

Improved cognitive abilities:
After HBOT, patients showed a significant increase in overall cognitive function, particularly in attention and executive functions (e.g., planning, problem-solving).

Better energy, sleep, psychological symptoms, and pain:
HBOT improved energy levels, sleep quality, reduced psychiatric symptoms, and decreased pain-related daily impairment.

Detectable brain changes:
Neuroimaging (MRI) demonstrated improved perfusion and structural changes in brain regions relevant to cognition and emotion – including the supramarginal gyrus, left supplementary motor area, and right insula.

Importance of the Results

This study is the first to show in a rigorous randomized design that HBOT can significantly improve the neurocognitive and psychological consequences of Post-COVID-19. The therapy appears to promote regeneration and cerebral blood flow, contributing to symptom relief.

Original Study on PubMed
Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial (PubMed ID: 35821512)

Conclusion

HBOT may represent a promising treatment option for patients with persistent Post-COVID symptoms, particularly those with cognitive impairments, fatigue, sleep disturbances, and pain. Future studies will help determine the optimal use of this therapy.

⚠️ Note: Always consult with your physician before starting HBOT to ensure individual suitability and safe application.

Authors

Zilberman-Itskovich S, Catalogna M, Sasson E, Elman-Shina K, Hadanny A, Lang E, Finci S, Polak N, Fishlev G, Korin C, Shorer R, Parag Y, Sova M, Efrati S

Publication Details

Type of study:

Prospective, randomized, double-blind, sham-controlled (Phase II, exploratory).

Publication:

Scientific Reports 12, Artikel-Nr. 11252 (12. Juli 2022)

Participants:

73 (HBOT n=37, Sham n=36); Symptomdauer ≥ 3 Monate nach gesicherter SARS-CoV-2-Infektion

Location:

Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel (Sagol Center), in Kooperation mit der Tel-Aviv Universität

Pages:

Band 12, Artikel 11252.

Band 12, Artikel 11252.

DOI:

10.1038/s41598-022-15565-0.

10.1038/s41598-022-15565-0.

PubMed ID:

35821512

35821512

Open in PubMed

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Legal Disclaimer: The effects described on this website are based on wellness observations and have not been evaluated by medical authorities. Our products are not medical devices and are not intended to diagnose, treat, or cure any disease. They do not replace professional medical advice. Always consult a physician before use, especially if you are pregnant, have a heart condition, or use a pacemaker. Use is at your own risk. No healing promises are made.

Legal Disclaimer:

The effects described on this website are based on wellness observations and have not been evaluated by medical authorities. Our products are not medical devices and are not intended to diagnose, treat, or cure any disease. They do not replace professional medical advice. Always consult a physician before use, especially if you are pregnant, have a heart condition, or use a pacemaker. Use is at your own risk. No healing promises are made.

Legal Disclaimer:

The effects described on this website are based on wellness observations and have not been evaluated by medical authorities. Our products are not medical devices and are not intended to diagnose, treat, or cure any disease. They do not replace professional medical advice. Always consult a physician before use, especially if you are pregnant, have a heart condition, or use a pacemaker. Use is at your own risk. No healing promises are made.