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HBOT and 9 of 12 hallmarks of aging in research – which approaches are discussed for the remaining 3?
HBOT is being studied in relation to 9 of the 12 hallmarks of aging. For a broader approach, targeted interventions in the areas of macroautophagy, chronic inflammation and dysbiosis are also discussed.
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How to address the missing 3 hallmarks of ageing
The three hallmarks that HBOT does not cover, or only covers to a limited extent, are:
Disabled macroautophagy (impaired macroautophagy)
Chronic inflammation (sometimes counterproductive with long-term use)
Dysbiosis (gut microbiome)
Hallmark | Approaches discussed in the literature | How well can it be combined with HBOT? |
|---|---|---|
10. Macroautophagy | 1. Spermidine (e.g., from wheat germ) 2. Intermittent fasting – each the subject of current studies | Combination with HBOT: hardly studied to date; please seek individual advice. |
11. Chronic inflammation | 1. Omega-3 fatty acids 2. Exercise and sauna 3. Plant polyphenols (e.g., curcumin, quercetin) – each the subject of current studies | Combination with HBOT: hardly studied to date. |
12. Dysbiosis | 1. Fibre- and polyphenol-rich diet (e.g., berries, cocoa, pomegranate) 2. Prebiotics and postbiotics (e.g., inulin, butyrate) – subject of current research | Independent of HBOT; please clarify nutrition questions individually. |
*The above summary is based on a response from the AI system Grok (version Grok 4, developed by xAI), queried on 29 November 2025.
Note: This article reflects third-party studies and testimonials. Our devices are not medical devices; we make no claims of healing or efficacy.
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Hallmarks of Aging