HBOT addresses 9/12 Hallmarks of Aging - How can the remaining 3 HoA be addressed?
HBOT addresses 9 of 12 Hallmarks of Aging. To achieve total optimization, you must close the gap by targeting macroautophagy, chronic inflammation, and dysbiosis through specific interventions.
Temps de lecture :
3
min.
Temps de lecture :
29 nov. 2025
Temps de lecture :
9 janv. 2026
How to Address the Missing 3 Hallmarks of Aging
The three hallmarks that HBOT does not cover or only weakly covers are therefore:
Disabled macroautophagy (disrupted macroautophagy)
Chronic inflammation (partially counterproductive with continuous application)
Dysbiosis (gut microbiome)
Hallmark | Best evidence-based interventions (2024/2025) | How well can it be combined with HBOT? | |
|---|---|---|---|
10. Macroautophagy | 1. Spermidine (1–3 mg/day or wheat germs) 2. Intermittent fasting / therapeutic fasting (16-48 h) 3. Rapamycin / Rapalogs (very strong, but side effects) 4. 17-α-Estradiol (men) or SERMs | ★★★★★ perfect - fasting + HBOT is an extremely strong duo | |
11. Chronic inflammation | 1. Curcumin + Piperine (liposomal, 500-1000 mg) 2. Omega-3 (2-4 g EPA/DHA) 3. Senolytics (Fisetin + Dasatinib or Quercetin intermittently) 4. Low-dose Naltrexone (LDN) 5. Sauna / heat shock (HSP70 ↑) | ★★★★☆ sauna in the evening after HBOT is ideal | |
12. Dysbiosis | 1. Akkermansia muciniphila + FOS/Inulin 2. Postbiotics (Butyrate, Urolithin A) 3. Fecal microbiota transplant (for severe dysbiosis) 4. Polyphenol-rich diet (berries, cocoa, pomegranate) | ★★★★★ completely independent - simply supplement daily |
*“The above summary is based on a response from the AI system Grok (version Grok 4, developed by xAI), queried on November 29, 2025.”
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